Endocrine Abstracts

Diabetes mellitus and abdominal obesity are considered to be risk factors for venous and arterial thrombosis, but till now it still remains unclear, what factor is a primary in the genesis of these abnormalities: fibrinolysis dysfunction, vascular endothelium impairment or pathology of the platelet homeostasis component.Forty-two persons included in the study were primary divided into 3 groups: 1 group – nearly healthy (10 males, 12 females), 2 grou...

The phosphodiesterase inhibitor pentoxifylline (PTX) is known to have immunomodulatory effects in some autoimmune diseases. The aim of our study was to assess the influence of glucocorticoids monotherapy and additive treatment with PTX on peripheral blood mononuclear cells (PBMC) proliferation and apoptosis in patients with Graves’ ophthalmopathy (GO).Eighteen patients with GO and 28 healthy controls were investigated. GO patients were divided into ...

Pentoxifylline (PTX), a phosphodiesterase inhibitor, has a positive therapeutic effect in some autoimmune diseases due to immunomodulatory action.The aim of the study was to assess the influence of PTX on apoptosis and peripheral blood mononuclear cells (PBMC) proliferation in patients with Graves’ ophthalmopathy (GO).Twenty-four patients with GO and 32 healthy controls were investigated. GO patients were divided into two grou...